Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Selegiline is an MAO-B inhibitor: it blocks monoamine oxidase B, an enzyme that breaks down dopamine in the brain. As tablets (Eldepryl, Zelapar) it is used for Parkinson's disease, alone early on or with levodopa; as a skin patch (Emsam), which also blocks MAO-A at higher doses, it is used for depression.
Selegiline is broken down mainly by CYP2B6 and CYP2A6 into desmethylselegiline and levo-amphetamine products. The gene study listed, in Parkinson's disease, looked at SLC22A1 (OCT1) for dose needs and side effects. The evidence is weak, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Eldepryl. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
SLC22A1 rs622342: Level 3. Dosage, Toxicity: Parkinson Disease. 1.
Studies of how much of the drug people needed or tolerated.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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