Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Rasagiline is an MAO-B inhibitor: it permanently blocks monoamine oxidase B, an enzyme that breaks down dopamine in the brain, so dopamine lasts longer. It is used for Parkinson's disease, alone in early stages or with levodopa to smooth out 'off' periods. It is sold as Azilect.
Rasagiline is broken down mainly by the liver enzyme CYP1A2. Studies have looked at CYP1A2, the transporters SLC22A1, ABCB1 and ABCC2, and COMT for its blood levels, and at the dopamine receptor gene DRD2 for response. The findings come from a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Rasagiline. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
DRD2 rs1076560: Level 3. Efficacy: Parkinson Disease. 1.
DRD2 rs2283265: Level 3. Efficacy: Parkinson Disease. 1.
Studies of how quickly the body processes this medication.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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