Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Propafenone is an antiarrhythmic of class 1C: it blocks sodium channels in the heart muscle, slowing the electrical signal, and also has a mild beta-blocking effect. It is used to keep a normal heart rhythm in people with atrial fibrillation and some other fast rhythms whose hearts are otherwise structurally healthy. It is sold as Rythmol, among other names.
Propafenone is broken down mainly by the liver enzyme CYP2D6. In people with no working CYP2D6 copies (poor metabolizers, about 5 to 10 in 100 people of European ancestry) its level is much higher and its beta-blocking effect stronger. The US drug label discusses this, especially when CYP3A4 is blocked at the same time by another medicine. DPWG has published a guideline on CYP2D6 and propafenone, and the US FDA lists the pair.
Clinical guidelines that name a gene for Propafenone. They sort people into groups by the gene copies they carry.
DPWG guideline: CYP2D6. CYP2D6 activity score 0 to 6 or more. 2011.
US FDA: CYP2D6. CYP2D6 activity score 0. Data that Support Therapeutic Management Recommendations.
Every published finding on gene variants and Propafenone. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
CYP2D6 CYP2D6*1, CYP2D6*2, CYP2D6*5, CYP2D6*10, CYP2D6*36: Level 1A · replicated. Metabolism/PK: Cardiac rhythm disease, Tachycardia. 3.
CYP2D6 CYP2D6*1, CYP2D6*10: Level 3. Efficacy: Cardiac rhythm disease. 1.
Studies of how quickly the body processes this medication.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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