Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Amiodarone is a class III antiarrhythmic with broad effects on potassium, sodium and calcium channels and beta receptors. It is used for serious ventricular rhythm problems and to control atrial fibrillation, especially in people with heart disease, and given by drip in cardiac arrest. It builds up in tissues over months and can affect the thyroid, lungs, liver and skin. It is sold as Cordarone and Pacerone.
Amiodarone is broken down by CYP3A4 and CYP2C8, and it blocks several CYP enzymes, raising the levels of warfarin and other medicines. The gene studies on it looked at genes linked to the QT interval of the heartbeat (NOS1AP, KCNH2, KCNE1) for the risk of drug-induced rhythm problems. The findings come from a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Amiodarone. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
NOS1AP rs10919035: Level 3. Toxicity: Long QT Syndrome. 1.
NOS1AP rs10800397: Level 3. Toxicity: Long QT Syndrome. 1.
KCNH2 rs12720441: Level 3. Toxicity: Torsades de Pointes. 1.
KCNE1 rs1805128: Level 3. Toxicity. 1.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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