Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Procainamide is a class 1A antiarrhythmic: it blocks sodium channels in the heart and slows conduction. It is given by drip in hospital to stop some fast heart rhythms, such as certain ventricular tachycardias and atrial fibrillation with an accessory pathway. Long-term use by mouth is now rare because of side effects. It was sold as Pronestyl.
Procainamide is converted by NAT2 into N-acetylprocainamide (NAPA), which also affects the heart rhythm. Slow acetylators, with two low-activity NAT2 copies, keep more procainamide itself and develop a drug-induced lupus earlier and more often on long-term treatment; the US FDA lists the pair as affecting safety. There is no CPIC or DPWG guideline.
Clinical guidelines that name a gene for Procainamide. They sort people into groups by the gene copies they carry.
US FDA: NAT2. Poor Metabolizer. Data that Indicate a Potential Impact on Safety or Response.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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