Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Prednisone is a corticosteroid prodrug that the liver turns into prednisolone, which calms inflammation and the immune system through the glucocorticoid receptor. It is one of the most used steroid tablets, for asthma and COPD flare-ups, rheumatoid arthritis, polymyalgia, inflammatory bowel disease, autoimmune conditions, allergic reactions and, in combinations such as CHOP, blood cancers. It is sold as Deltasone, among other names.
Prednisone is activated by 11-beta-hydroxysteroid dehydrogenase and then broken down by CYP3A4. Studies have looked at NR3C1, the gene for the glucocorticoid receptor, for response, and at ABCB1 and other genes for side effects, partly in children treated for leukaemia. The findings come from a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Prednisone. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
GSTA1 rs3957357: Level 3. Efficacy: Lymphoma, Large B-Cell, Diffuse. 2.
ABCB1 rs1045642: Level 3. Other: Organ Transplantation, Transplantation. 1.
CTLA4 rs4553808: Level 3. Toxicity. 1.
GATA3 rs3824662: Level 3. Efficacy. 1.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Corticosteroids (class) (Corticosteroids)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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