Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Corticosteroids are a class of medicines modelled on cortisol, the body's own stress hormone. They act on the glucocorticoid receptor to calm inflammation and the immune system. They are used as inhalers for asthma and COPD, as creams for skin conditions, as tablets or injections for arthritis, inflammatory bowel disease, autoimmune conditions and allergic reactions, and in cancer care. The class includes prednisone, prednisolone, dexamethasone, budesonide, fluticasone and others. This page collects studies on the class as a whole.
Most studies here concern inhaled corticosteroids in asthma and looked for genes that predict how well lung function improves: GLCCI1, CRHR1 (the receptor for the hormone that starts the stress response), STIP1 and FKBP5, which help regulate the glucocorticoid receptor. GLCCI1 drew attention after a genome-wide study, but later studies did not all confirm it. There is no CPIC or DPWG guideline for corticosteroids.
Every published finding on gene variants and Corticosteroids. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
CRHR1 rs1876828: Level 3. Efficacy: Asthma. 6.
ADRB2 rs1042713: Level 3. Efficacy: Asthma. 3.
ADRB2 rs1042713: Level 3. Efficacy: Asthma. 2.
DCAF4 rs7160796: Level 3. Efficacy: Asthma. 1.
Studies of how well it worked in people carrying a variant.
Studies of how much of the drug people needed or tolerated.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Glucocorticoids (class) (Corticosteroids)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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