Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Fluticasone propionate is a potent corticosteroid used mainly where it is applied, because the body clears what is swallowed very efficiently. Inhaled, it prevents asthma symptoms and COPD flare-ups, often combined with salmeterol (Advair, Seretide); as a nasal spray it treats allergic rhinitis and nasal polyps; it is also a skin cream. It is sold as Flovent, Flonase and Flixotide, among other names.
Fluticasone is broken down by CYP3A4, so strong CYP3A4 blockers such as ritonavir can raise its levels enough to cause body-wide steroid effects; that interaction matters more than genes. Studies on inhaled fluticasone in asthma looked at CRHR1, GLCCI1, CA10, ORMDL3 and ADRB2 for how much lung function improved. The findings come from a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Flonase. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
GLCCI1 rs37973: Level 3. Efficacy: Asthma. 1.
rs1786929: Level 3. Efficacy: Asthma. 1.
CA10 rs967676: Level 3. Efficacy: Asthma. 1.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Corticosteroids (class) (Corticosteroids)
Glucocorticoids (class) (Corticosteroids)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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