Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Prednisolone is a corticosteroid, the active form of prednisone, that calms inflammation and the immune system through the glucocorticoid receptor. It is used for asthma and COPD flare-ups, allergic reactions, rheumatoid arthritis, inflammatory bowel disease, autoimmune conditions and some blood cancers, and as eye drops. It is sold as Orapred, Prelone and many other names.
Prednisolone is broken down by CYP3A4 and pumped out of cells by ABCB1. Studies have looked at ABCB1 variants for response and side effects in conditions such as nephrotic syndrome and inflammatory bowel disease, and at immune genes such as TLR4 and GATA3. The findings come from single or a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Prednisolone. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
PNPLA3 rs738409: Level 3. Toxicity: Acute lymphoblastic leukemia. 2.
DSE;TSPYL1 rs3828743: Level 3. Efficacy: Prostatic Neoplasms. 1.
ABCB1 rs2229109: Level 3. Efficacy: Acute lymphoblastic leukemia. 1.
ABCB1 rs1045642: Level 3. Toxicity: Kidney Transplantation. 1.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Corticosteroids (class) (Corticosteroids)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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