Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Pertussis vaccines protect against whooping cough. Today's acellular vaccines contain purified parts of the Bordetella pertussis bacterium and are given combined with diphtheria and tetanus vaccines (DTaP for children, Tdap for adolescents and adults); vaccinating during pregnancy protects newborns in their first months.
The gene studies on pertussis vaccines looked at TLR4, a receptor of the innate immune system that recognises bacterial components, for the strength of the antibody response after vaccination. The findings come from a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Pertussis Vaccine. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
TLR4 rs4986790: Level 3. Efficacy. 1.
TLR4 rs2770150: Level 3. Efficacy. 1.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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