Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Pegaptanib was the first anti-VEGF treatment for the eye: an aptamer, a short strand of RNA that binds VEGF-165 and stops it from driving abnormal blood vessel growth. Injected into the eye, it was used for wet age-related macular degeneration, and has been replaced by more effective antibodies such as ranibizumab and aflibercept. It was sold as Macugen.
Pegaptanib acts in the eye and is broken down by nucleases. The gene study listed looked at VEGFA, the gene for its target, for how much vision changed after treatment. The evidence is weak, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Pegaptanib. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
VEGFA rs2010963: Level 3. Efficacy: Choroidal Neovascularization. 1.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Anti-VEGF Agents (class) (Anti-VEGF Agents)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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