Nimodipine (Nimotop)

Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.

About Nimodipine

What it is

Nimodipine is a calcium channel blocker of the dihydropyridine group that acts especially on blood vessels in the brain. It is used after a subarachnoid haemorrhage (bleeding around the brain from a burst aneurysm) to reduce damage from blood vessel spasm. It is sold as Nimotop and Nymalize.

How genes come into it

Nimodipine is broken down almost entirely by CYP3A4 (and CYP3A5) on its first pass through the gut and liver. Studies have looked at CYP3A5 and ABCB1 for its levels, and at the calcium channel genes CACNA1C and CACNA1B for response. The findings come from a few studies, and there is no CPIC or DPWG guideline.

What research found

Every published finding on gene variants and Nimodipine. Upload your DNA file to see which of these rows apply to you.

Rated evidence (3 rated variants)

PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.

CACNA1C rs2239050: Level 3. Efficacy. 1.

CYP3A5 CYP3A5*1, CYP3A5*3: Level 3. Metabolism/PK. 1.

CACNA1C rs2239128: Level 3. Efficacy. 1.

Response (8 findings)

Studies of how well it worked in people carrying a variant.

CACNA1B rs2739258: Genotypes AG + GG is associated with increased clinical benefit to nicardipine or nimodipine in people with Bipolar Disorder as compared to genotype AA.

CACNA1B rs2739260: Genotypes AG + GG is associated with increased clinical benefit to nicardipine or nimodipine in people with Bipolar Disorder as compared to genotype AA.

CACNA1C rs2239050: Genotype CG is associated with increased response to nimodipine in healthy individuals as compared to genotype CC.

CACNA1C rs2239128: Genotype CC is associated with increased response to nimodipine in healthy individuals as compared to genotype CT.

Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.

Related Drugs

More drugs from the same category

Calan (Calcium Channel Blockers)

Calcium Channel Blockers (class) (Calcium Channel Blockers)

Cardene (Calcium Channel Blockers)

Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.

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Content updated September 2026.

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