Procardia

Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.

About Procardia

What it is

Nifedipine is a calcium channel blocker of the dihydropyridine group: it relaxes the muscle of artery walls, so they widen and blood pressure falls. As extended-release tablets it treats high blood pressure and angina; it is also used for high blood pressure in pregnancy, to delay preterm labour, and for Raynaud's phenomenon. It is sold as Procardia and Adalat, among other names.

How genes come into it

Nifedipine is broken down almost entirely by CYP3A4 (and CYP3A5), which is why grapefruit and other CYP3A4 blockers raise its levels. Studies have looked at CYP3A4 and CYP3A5 variants for its levels, and at the calcium channel gene CACNA1C, ADRA1A and SLC14A2 for blood pressure response. The findings come from a few studies, and there is no CPIC or DPWG guideline.

What research found

Every published finding on gene variants and Procardia. Upload your DNA file to see which of these rows apply to you.

Rated evidence (5 rated variants)

PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.

SLC14A2 rs1123617: Level 3. Efficacy: Hypertension. 1.

SLC14A2 rs3745009: Level 3. Efficacy: Hypertension. 1.

CYP3A5 rs776746: Level 3. Other: Pregnancy. 1.

CYP3A4 CYP3A4*1, CYP3A4*17: Level 3. Metabolism/PK. 1.

Metabolism (6 findings)

Studies of how quickly the body processes this medication.

CYP3A5 rs776746: Genotypes CT + TT are associated with increased clearance of nifedipine in women with Pregnancy as compared to genotype CC.

CYP3A4 CYP3A4*1, CYP3A4*17: CYP3A4 *17 is associated with decreased metabolism of nifedipine as compared to CYP3A4 *1.

CYP3A4 CYP3A4*1, CYP3A4*18: CYP3A4 *18 is not associated with decreased metabolism of nifedipine as compared to CYP3A4 *1.

CYP3A4 rs2740574: Genotype CC is not associated with metabolism of nifedipine in healthy individuals as compared to genotype TT.

Response (10 findings)

Studies of how well it worked in people carrying a variant.

ADIPOQ rs2241766: Genotype GT is associated with increased response to hydralazine, Methyldopa or nifedipine in women with Pre-Eclampsia and Pregnancy.

ADRA1A rs1048101: Genotypes AA + AG are associated with increased response to nifedipine in people with Hypertension as compared to genotype GG.

CACNA1C rs2238032: Genotype TT is associated with increased response to lacidipine, nifedipine or nitrendipine in people with Hypertension as compared to genotypes GG + GT.

MMP9 rs3918242: Genotype CT is associated with decreased response to Antihypertensives, hydralazine, Methyldopa or nifedipine in people with Gestational hypertension as compared to genotype CC.

Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.

Related Drugs

More drugs from the same category

Calan (Calcium Channel Blockers)

Calcium Channel Blockers (class) (Calcium Channel Blockers)

Cardene (Calcium Channel Blockers)

Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.

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Content updated September 2026.

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