Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Metoclopramide blocks dopamine D2 receptors in the gut and the brain's vomiting centre, and speeds up stomach emptying. It is used for nausea and vomiting, for diabetic gastroparesis (slow stomach emptying) and for acid reflux that has not responded to other treatment. Long-term use carries a risk of tardive dyskinesia, so treatment is kept short. It is sold as Reglan and Maxolon, among other names.
Metoclopramide is broken down partly by CYP2D6. People with no working CYP2D6 copies (poor metabolizers) reach higher levels and are more prone to movement side effects, which the US label addresses; the US FDA lists the pair. There is no CPIC or DPWG guideline.
Clinical guidelines that name a gene for Metoclopramide. They sort people into groups by the gene copies they carry.
US FDA: CYP2D6. CYP2D6 activity score 0. 2017.
US FDA: CYP2D6. CYP2D6 activity score 0. Data that Support Therapeutic Management Recommendations.
Every published finding on gene variants and Metoclopramide. Upload your DNA file to see which of these rows apply to you.
Studies of how quickly the body processes this medication.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Advair (Corticosteroid + LABA)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
ReadYourDNA provides educational interpretation of DNA data you already have. It is not diagnostic, not a substitute for professional medical advice, diagnosis, or treatment, and is not intended to diagnose, treat, cure, or prevent any disease. Talk to a clinician before acting on any result.
Raw DNA Data Reports for 23andMe & AncestryDNA · About ReadYourDNA · FAQ · Methodology & Science · Pricing · Support and complaints · Legal & Contact · Health Traits · Pharmacogenomics · Carrier Status · Variant Explorer · The Human Karyotype · Privacy Policy · Terms of Service · Accessibility · Consumer Health Data Privacy · Your Privacy Choices · Editorial Standards · Your Data, Checkable · Sample Report · ReadYourDNA and Promethease compared · What is inside a 23andMe raw data file · What is inside an AncestryDNA raw data file · What a chatbot can and cannot do with your raw DNA file · Where a raw DNA file can still be uploaded in 2026
Written, maintained and operated by Martin Pechhacker, sole proprietor, Vienna, Austria. Trade register GISA 40064420. support@readyourdna.com