Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Methylprednisolone is a corticosteroid, somewhat stronger than prednisolone, that calms inflammation and the immune system. As tablets (Medrol) it is used for many inflammatory and allergic conditions; as high-dose drips (Solu-Medrol) for multiple sclerosis relapses, organ transplant rejection and severe flares of autoimmune disease; and as joint injections (Depo-Medrol).
Methylprednisolone is broken down mainly by CYP3A4 and is pumped out of cells by ABCB1. The gene study listed looked at ABCB1 for side effects. The evidence is weak, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Medrol. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
ABCB1 rs1045642: Level 3. Toxicity: Kidney Transplantation. 1.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Corticosteroids (class) (Corticosteroids)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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