Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Follitropin beta is recombinant follicle-stimulating hormone (FSH), made in cultured cells. Injected, it stimulates the ovaries to grow follicles in fertility treatment such as IVF and ovulation induction, and helps sperm production in some men with hormone deficiency. It is sold as Follistim and Puregon.
As a protein hormone, follitropin beta is not handled by drug-processing enzymes. The gene studies on it looked at FSHR, the gene for the FSH receptor: its common Asn680Ser variant (rs6166) was linked in some studies to how strongly the ovaries responded, how much FSH was needed and the chance of ovarian hyperstimulation. The findings come from a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Follistim. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
FSHR rs6166: Level 3. Efficacy: Infertility, Female, Ovarian hyperstimulation syndrome. 1.
FSHR rs6166: Level 3. Dosage: Infertility disorder. 1.
FSHR rs6166: Level 3. Dosage. 1.
FSHR rs6166: Level 3. Efficacy: Infertility disorder. 1.
Studies of how well it worked in people carrying a variant.
Studies of how much of the drug people needed or tolerated.
Studies of side effects in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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