Felodipine (Plendil)

Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.

About Felodipine

What it is

Felodipine is a calcium channel blocker of the dihydropyridine group: it relaxes the muscle of artery walls, so they widen and blood pressure falls. It is used for high blood pressure and angina, as an extended-release tablet. Grapefruit juice raises its levels markedly. It is sold as Plendil, among other names.

How genes come into it

Felodipine is broken down almost entirely by CYP3A4 in the gut wall and liver, which is why grapefruit, a CYP3A4 blocker, has such a large effect on it. The few gene studies on it looked at CYP3A5 and ABCG2 for its levels and at the calcium channel gene CACNA1C for blood pressure response. The findings come from a few studies, and there is no CPIC or DPWG guideline.

What research found

Every published finding on gene variants and Felodipine. Upload your DNA file to see which of these rows apply to you.

Metabolism (2 findings)

Studies of how quickly the body processes this medication.

ABCG2 rs2231142: Genotype TT is associated with increased exposure to felodipine in healthy individuals as compared to genotypes GG + GT.

CYP3A5 CYP3A5*1, CYP3A5*3: CYP3A5 *3/*3 is associated with increased exposure to felodipine in healthy individuals as compared to CYP3A5 *1/*3.

Response (3 findings)

Studies of how well it worked in people carrying a variant.

CACNA1C rs2238032: Genotype TT is associated with increased response to amlodipine or felodipine in people with Hypertension as compared to genotypes GG + GT.

CACNA1C rs2239050: Genotype GG is associated with increased response to amlodipine and felodipine in people with Hypertension as compared to genotype CG.

CACNA1C rs2239128: Allele C is associated with increased response to amlodipine and felodipine in people with Hypertension as compared to allele T.

Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.

Related Drugs

More drugs from the same category

Calan (Calcium Channel Blockers)

Calcium Channel Blockers (class) (Calcium Channel Blockers)

Cardene (Calcium Channel Blockers)

Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.

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Content updated September 2026.

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