Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Edoxaban is a direct oral anticoagulant (DOAC): it blocks factor Xa, a central clotting enzyme, so blood takes longer to clot. Taken once a day without regular blood tests, it is used to lower the chance of stroke in atrial fibrillation and to treat clots in the legs and lungs. It is sold as Savaysa and Lixiana.
Edoxaban is cleared about half by the kidneys and half by other routes, with little broken down by CYP3A4; it is a substrate of the transporter ABCB1 and is taken into the liver partly by SLCO1B1. Studies have looked at ABCB1, CYP3A5, POR and SLCO1B1 for its blood levels, with small effects. There is no CPIC or DPWG guideline.
Every published finding on gene variants and Edoxaban. Upload your DNA file to see which of these rows apply to you.
Studies of how quickly the body processes this medication.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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