Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Apixaban is a direct oral anticoagulant (DOAC): it blocks factor Xa, a central clotting enzyme, so blood takes longer to clot. It does not need regular blood tests. It is used to lower the chance of stroke in atrial fibrillation, to prevent and treat clots in the legs and lungs, and after hip or knee replacement. It is sold as Eliquis.
Apixaban is broken down mainly by CYP3A4, with help from CYP3A5, and pumped out of cells by ABCB1 and ABCG2; part is cleared by the kidneys. Studies have linked ABCG2 and CYP3A5 variants to modest differences in its blood levels, and ABCB1 to bleeding, with mixed results. No gene changes its effect the way VKORC1 changes warfarin's, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Apixaban. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
ABCG2 rs2231142: Level 3. Metabolism/PK: Atrial Fibrillation. 2.
CYP3A5 rs776746: Level 3. Metabolism/PK: Atrial Fibrillation. 2.
ABCB1 rs4148738: Level 3. Toxicity. 1.
Studies of how quickly the body processes this medication.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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