Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Dopamine agonists are a class of medicines that activate dopamine receptors directly. They include pramipexole, ropinirole, rotigotine (as a patch) and apomorphine for Parkinson's disease and restless legs syndrome, and bromocriptine and cabergoline, which lower prolactin. Impulse control problems are a known side effect of the Parkinson's medicines. This page collects studies on the class as a group.
The single gene study listed for the class, in Parkinson's disease, looked at SLC22A1 (OCT1), an organic cation transporter, for dose needs and side effects. The evidence is weak, and there is no CPIC or DPWG guideline. Ropinirole is broken down by CYP1A2, while pramipexole is cleared by the kidneys; each has its own page.
Every published finding on gene variants and Dopamine Agonists. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
SLC22A1 rs622342: Level 3. Dosage, Toxicity: Parkinson Disease. 1.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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