Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Dihydropyridines are the largest group of calcium channel blockers. They act mainly on the muscle of artery walls, widening the arteries and lowering blood pressure, with little direct effect on the heart rate. The group includes amlodipine, nifedipine, felodipine, lercanidipine, nimodipine and others, used for high blood pressure, angina and Raynaud's phenomenon. This page collects studies on the group as a whole.
Nearly all dihydropyridines are broken down by CYP3A4, with CYP3A5 contributing, which is why grapefruit and CYP3A4 blockers raise their levels. The gene studies listed looked at CYP3A5, NUMA1 and NOS1AP. The findings come from a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Dihydropyridines. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
NOS1AP rs10494366: Level 3. Toxicity. 1.
Studies that do not fall into the groups above.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Calan (Calcium Channel Blockers)
Calcium Channel Blockers (class) (Calcium Channel Blockers)
Cardene (Calcium Channel Blockers)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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