Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Dacarbazine (DTIC) is an alkylating chemotherapy medicine that the liver activates into a compound that adds methyl groups to DNA. It is part of the ABVD combination for Hodgkin lymphoma, and is used for metastatic melanoma and some soft tissue sarcomas. It is sold as DTIC-Dome, among other names.
Dacarbazine is activated by CYP1A2, CYP1A1 and CYP2E1. The gene studies listed looked at the glutathione transferase genes GSTM1 and GSTT1, which are entirely deleted in many people, for response and side effects in Hodgkin lymphoma. The findings come from a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Dacarbazine. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
GSTM1 GSTM1 non-null, GSTM1 null: Level 3. Efficacy, Toxicity. 1.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Alkylating Agents (class) (Alkylating Agents)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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