Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Cefotaxime is a third-generation cephalosporin antibiotic that blocks bacteria from building their cell wall. Given by injection or drip, it treats meningitis, sepsis, pneumonia and other serious infections, and is often used in newborns. It is sold as Claforan, among other names.
Cefotaxime is partly broken down to an active product and cleared by the kidneys, where the transporter SLC22A8 (OAT3) moves it into the urine. The gene study listed looked at SLC22A8 variants for its clearance. The findings come from a single study, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Cefotaxime. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
SLC22A8 rs11568482: Level 3. Metabolism/PK. 1.
Studies of how quickly the body processes this medication.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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