Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Cannabinoids are substances that act on the body's cannabinoid receptors (CB1 and CB2). They include THC and cannabidiol (CBD) from the cannabis plant and medicines made from them: dronabinol and nabilone for nausea from chemotherapy and appetite loss, nabiximols (Sativex) for muscle stiffness in multiple sclerosis, and cannabidiol (Epidiolex) for some severe childhood epilepsies. This page collects studies on cannabinoids as a group.
THC is broken down mainly by CYP2C9, and people with the reduced-function CYP2C9*3 version have shown higher THC levels; cannabidiol is broken down by CYP2C19 and CYP3A4. The gene studies on this page, mostly on cannabis dependence, looked at OPRM1, FAAH (which breaks down the body's own cannabinoids) and others. The findings are weak, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Cannabinoids. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
KAT2B rs9829896: Level 3. Toxicity: Substance-Related Disorders. 1.
OPRM1 rs1799971: Level 3. Toxicity: Marijuana Abuse. 1.
FAAH rs324420: Level 3. Toxicity: Substance-Related Disorders. 1.
OPRM1 rs1799971: Level 4. Toxicity: Substance-Related Disorders. 5.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
ReadYourDNA provides educational interpretation of DNA data you already have. It is not diagnostic, not a substitute for professional medical advice, diagnosis, or treatment, and is not intended to diagnose, treat, cure, or prevent any disease. Talk to a clinician before acting on any result.
Raw DNA Data Reports for 23andMe & AncestryDNA · About ReadYourDNA · FAQ · Methodology & Science · Pricing · Support and complaints · Legal & Contact · Health Traits · Pharmacogenomics · Carrier Status · Variant Explorer · The Human Karyotype · Privacy Policy · Terms of Service · Accessibility · Consumer Health Data Privacy · Your Privacy Choices · Editorial Standards · Your Data, Checkable · Sample Report · ReadYourDNA and Promethease compared · What is inside a 23andMe raw data file · What is inside an AncestryDNA raw data file · What a chatbot can and cannot do with your raw DNA file · Where a raw DNA file can still be uploaded in 2026
Written, maintained and operated by Martin Pechhacker, sole proprietor, Vienna, Austria. Trade register GISA 40064420. support@readyourdna.com