Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Cannabidiol (CBD) is a non-intoxicating compound from the cannabis plant. As the prescription medicine Epidiolex (Epidyolex) it is used for seizures in Dravet syndrome, Lennox-Gastaut syndrome and tuberous sclerosis complex; it is also widely sold as a supplement, where quality and content vary. How it reduces seizures is not fully understood.
Cannabidiol is broken down mainly by CYP2C19 and CYP3A4, and it blocks CYP2C19 itself, notably raising the active breakdown product of clobazam when the two are combined. The gene studies listed, from a study in children with epilepsy, looked at ABCC5, AOC1 and SLC15A1 for response. The findings come from a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Cannabidiol. Upload your DNA file to see which of these rows apply to you.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Cannabinoids (class) (Cannabinoids)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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