Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Bucindolol is an experimental beta blocker with mild vasodilating properties. It was tested in heart failure in the BEST trial, which did not show an overall survival benefit, and is being developed for atrial fibrillation in people with a particular beta-1 receptor genotype. It is not approved for routine use.
Bucindolol is a prominent example of a medicine developed around a gene. Analyses of the BEST trial found that people with two copies of the Arg389 version of ADRB1, the beta-1 receptor gene, benefited markedly while others did not, and the ADRA2C deletion variant also modified the effect. A later trial (GENETIC-AF) compared it with metoprolol in this genotype group. There is no CPIC or DPWG guideline.
Every published finding on gene variants and Bucindolol. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
ADRB1 rs1801253: Level 3. Efficacy: Heart Failure. 2.
ADRA2C rs61767072: Level 3. Efficacy: Heart Failure. 1.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Beta Blockers (class) (Beta Blockers)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
ReadYourDNA provides educational interpretation of DNA data you already have. It is not diagnostic, not a substitute for professional medical advice, diagnosis, or treatment, and is not intended to diagnose, treat, cure, or prevent any disease. Talk to a clinician before acting on any result.
Raw DNA Data Reports for 23andMe & AncestryDNA · About ReadYourDNA · FAQ · Methodology & Science · Pricing · Support and complaints · Legal & Contact · Health Traits · Pharmacogenomics · Carrier Status · Variant Explorer · The Human Karyotype · Privacy Policy · Terms of Service · Accessibility · Consumer Health Data Privacy · Your Privacy Choices · Editorial Standards · Your Data, Checkable · Sample Report · ReadYourDNA and Promethease compared · What is inside a 23andMe raw data file · What is inside an AncestryDNA raw data file · What a chatbot can and cannot do with your raw DNA file · Where a raw DNA file can still be uploaded in 2026
Written, maintained and operated by Martin Pechhacker, sole proprietor, Vienna, Austria. Trade register GISA 40064420. support@readyourdna.com