Bisoprolol (Zebeta)

Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.

About Bisoprolol

What it is

Bisoprolol is a beta blocker that acts very selectively on the heart (beta-1): it blocks adrenaline there, slowing the heart rate and lowering blood pressure. It is used for high blood pressure, angina, heart failure and to control the heart rate in atrial fibrillation. It is sold as Concor, Zebeta and Cardicor, among other names.

How genes come into it

Bisoprolol is cleared half by the kidneys unchanged and half by the liver, mainly by CYP3A4 with a small part by CYP2D6, so CYP2D6 variants matter much less than for metoprolol. Studies have looked at CYP2D6, CYP3A5 and the beta-1 receptor gene ADRB1 for heart rate and blood pressure response. The findings come from a few studies, and there is no CPIC or DPWG guideline.

What research found

Every published finding on gene variants and Bisoprolol. Upload your DNA file to see which of these rows apply to you.

Rated evidence (2 rated variants)

PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.

rs12346562: Level 3. Efficacy: Hypertension. 1.

ACY3 rs2514036: Level 3. Efficacy: Hypertension. 1.

Metabolism (4 findings)

Studies of how quickly the body processes this medication.

CYP2D6 rs1080985: Genotype CC is associated with decreased concentrations of bisoprolol in people with Cardiovascular Diseases as compared to genotypes CG + GG.

CYP2D6 rs1080985: Allele G is associated with increased concentrations of bisoprolol in people with Acute coronary syndrome as compared to allele C.

CYP2D6 rs3892097: Genotypes CT + TT is associated with increased concentrations of bisoprolol in people with Acute coronary syndrome as compared to genotype CC.

CYP3A5 rs776746: Genotype TT is associated with decreased concentrations of bisoprolol in people with Acute coronary syndrome as compared to genotypes CC + CT.

Response (6 findings)

Studies of how well it worked in people carrying a variant.

ACY3 rs2514036: Allele T is associated with increased response to bisoprolol in men with Hypertension as compared to allele C.

KCNH2 rs1137617: Genotype GG is associated with response to atenolol, bisoprolol, Celiprolol or doxazosin in people with Essential hypertension as compared to genotypes AA + AG.

rs12346562: Genotypes AA + AC is associated with increased response to bisoprolol in people with Hypertension as compared to genotype CC.

ADRB1 rs1801252: Genotype AA is associated with increased response to bisoprolol in people with Hypertension as compared to genotype AG.

Dosing (1 finding)

Studies of how much of the drug people needed or tolerated.

ADRB1 rs1801253: Genotype CC is not associated with dose of bisoprolol in people with Coronary Artery Disease as compared to genotypes CG + GG.

Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.

Related Drugs

More drugs from the same category

Beta Blockers (class) (Beta Blockers)

Betapace (Beta Blockers)

Bucindolol (Beta Blockers)

Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.

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Content updated September 2026.

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