Your result, the one DNA position behind it, and what the research says.
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Faces differ in vertical proportion: how tall the face is between brow and chin relative to its width. Orthodontists have measured this for a century and call the extremes long-face and short-face patterns. RUNX2 is the master switch that turns cells into bone-builders, and it sets the pace at which the facial skeleton grows, so it is a mechanically sensible place for such differences to originate.
Good to know: Facial proportion is measured on x-rays, not by eye. RUNX2 sets the pace at which the facial skeleton grows. Face shape draws on very many genes, so any single one contributes little.
Fun fact: RUNX2 carries neighboring runs of glutamines and alanines, and the ratio between their lengths tracks with facial length, both across dog breeds and across carnivore species.
Discovery: RUNX2 variants were tied to vertical facial patterns in orthodontic genetics.
The single variant behind this trait
Gene: RUNX2
Variant (rsID): rs1200425
Location: Chr 6:45,559,395
dbSNP rs1200425
Content updated September 2026.
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