Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Zuclopenthixol is a first-generation antipsychotic of the thioxanthene group that blocks dopamine D1 and D2 receptors. It is used for schizophrenia and other psychoses, as tablets, as a short-acting injection for acute episodes, and as a long-acting injection. It is sold as Clopixol and Cisordinol, among other names; it is not marketed in the US.
Zuclopenthixol is broken down mainly by the liver enzyme CYP2D6. People with little or no CYP2D6 activity have clearly higher levels, and people with extra copies lower ones. DPWG has published a guideline on CYP2D6 and zuclopenthixol, and all the studies on this page concern CYP2D6.
Clinical guidelines that name a gene for Zuclopenthixol. They sort people into groups by the gene copies they carry.
DPWG guideline: CYP2D6. CYP2D6 activity score 0 to 6 or more. 2024.
Every published finding on gene variants and Zuclopenthixol. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
CYP2D6 CYP2D6*1, CYP2D6*3, CYP2D6*4: Level 1A · replicated. Metabolism/PK: Schizophrenia. 2.
Studies of how quickly the body processes this medication.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Antipsychotics (class) (Antipsychotics)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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