Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Antipsychotics are a class of medicines that act mainly by blocking or moderating dopamine D2 receptors, many of them also serotonin receptors. They are used for schizophrenia and other psychoses, for mania in bipolar disorder, and some for agitation, tics or as add-ons in depression. The class includes older agents such as haloperidol and newer ones such as risperidone, olanzapine, quetiapine and aripiprazole. This page collects studies that looked at antipsychotics as a group.
Studies of the class as a whole have looked at the dopamine receptor gene DRD2, COMT, BDNF and others for response, and at genes such as MC4R and HTR2C for weight gain and movement side effects; the results are mixed and none has reached a guideline. The firm evidence is for individual medicines and the enzymes that break them down, chiefly CYP2D6 (aripiprazole, risperidone, haloperidol and others) and CYP3A4 (quetiapine), each on its own page.
Every published finding on gene variants and Antipsychotics. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
CYP2D6 CYP2D6*3, CYP2D6*4, CYP2D6*5, CYP2D6*6, CYP2D6*7, CYP2D6*10, CYP2D6*14: Level 3. Toxicity: Dystonia. 12.
LEP rs7799039: Level 3. Toxicity: Autism Spectrum Disorder, Mood Disorder. 4.
MC4R rs489693: Level 3. Toxicity: Weight gain. 4.
DRD2 rs1799732: Level 3. Toxicity: Psychotic Disorder. 4.
Studies of how quickly the body processes this medication.
Studies of how well it worked in people carrying a variant.
Studies of how much of the drug people needed or tolerated.
Studies of side effects in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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