Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Ziprasidone is an antipsychotic that blocks dopamine D2 and serotonin 5-HT2A receptors and also acts on several other serotonin receptors. It is used for schizophrenia and for mania in bipolar disorder, and as an injection for acute agitation. It causes less weight gain than many antipsychotics, but can lengthen the QT interval of the heartbeat. It is sold as Geodon and Zeldox.
Ziprasidone is broken down mainly by aldehyde oxidase, with a smaller part by CYP3A4, so the common CYP gene differences matter little. The gene studies on this page come mostly from the large CATIE trial of antipsychotics and flagged genes such as RGS4, SV2C and others for response; none has been confirmed independently. There is no CPIC or DPWG guideline.
Every published finding on gene variants and Ziprasidone. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
RGS4 rs951439: Level 3. Efficacy: Schizophrenia. 1.
EIF2AK4 rs2412459: Level 3. Efficacy: Schizophrenia. 1.
rs7912580: Level 3. Efficacy: Schizophrenia. 1.
Studies of how quickly the body processes this medication.
Studies of how well it worked in people carrying a variant.
CDH4 rs4925300: Allele A is associated with response to ziprasidone in people with Schizophrenia.
CNTN4 rs17194378: Allele A is associated with response to ziprasidone in people with Schizophrenia.
LYN rs1546519: Allele G is associated with response to ziprasidone in people with Schizophrenia.
NALCN rs9585618: Allele C is associated with response to ziprasidone in people with Schizophrenia.
Studies of how much of the drug people needed or tolerated.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Antipsychotics (class) (Antipsychotics)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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