Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Vortioxetine is an antidepressant with a mixed action: it blocks the reuptake of serotonin and also acts directly on several serotonin receptors. It is used for major depression in adults. It is sold as Trintellix and Brintellix, among other names.
Vortioxetine is broken down mainly by the liver enzyme CYP2D6. People with no working CYP2D6 copies (poor metabolizers) have roughly twice the blood level of people with normal activity, and the US drug label addresses them. CPIC has published a guideline on CYP2D6 and vortioxetine, and the US FDA lists the pair. Only a few studies on this medicine have looked at genes.
Clinical guidelines that name a gene for Vortioxetine. They sort people into groups by the gene copies they carry.
CPIC guideline: CYP2D6. CYP2D6 activity score 0 to 6 or more. Strong. 2023.
US FDA: CYP2D6. CYP2D6 activity score 0.
US FDA: CYP2D6. CYP2D6 activity score 0. Data that Support Therapeutic Management Recommendations.
Every published finding on gene variants and Vortioxetine. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
CYP2D6 CYP2D6*1, CYP2D6*4, CYP2D6*10: Level 1A · replicated. Metabolism/PK. 2.
Studies of how quickly the body processes this medication.
Studies of side effects in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Antidepressants (class) (Antidepressants)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
ReadYourDNA provides educational interpretation of DNA data you already have. It is not diagnostic, not a substitute for professional medical advice, diagnosis, or treatment, and is not intended to diagnose, treat, cure, or prevent any disease. Talk to a clinician before acting on any result.
Raw DNA Data Reports for 23andMe & AncestryDNA · About ReadYourDNA · FAQ · Methodology & Science · Pricing · Support and complaints · Legal & Contact · Health Traits · Pharmacogenomics · Carrier Status · Variant Explorer · The Human Karyotype · Privacy Policy · Terms of Service · Accessibility · Consumer Health Data Privacy · Your Privacy Choices · Editorial Standards · Your Data, Checkable · Sample Report · ReadYourDNA and Promethease compared · What is inside a 23andMe raw data file · What is inside an AncestryDNA raw data file · What a chatbot can and cannot do with your raw DNA file · Where a raw DNA file can still be uploaded in 2026
Written, maintained and operated by Martin Pechhacker, sole proprietor, Vienna, Austria. Trade register GISA 40064420. support@readyourdna.com