Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Valganciclovir is an oral prodrug of ganciclovir, an antiviral that, once activated inside infected cells, blocks the DNA polymerase of cytomegalovirus (CMV). It is used to prevent CMV disease after organ transplants and to treat CMV infection of the eye in people with HIV, and for congenital CMV in babies. Low blood counts are its main side effect. It is sold as Valcyte.
Valganciclovir is converted to ganciclovir in the gut and liver, and ganciclovir is cleared unchanged by the kidneys. The gene studies listed looked at ABCC4 and ABCB1, transporters that move ganciclovir out of cells, for side effects such as low white cell counts. The findings come from a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Valganciclovir. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
ABCC4 rs11568658: Level 3. Toxicity: Kidney Transplantation. 1.
ABCB1 rs2229109: Level 3. Toxicity: Kidney Transplantation. 1.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Agenerase (Protease Inhibitors)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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