Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Letermovir is an antiviral that blocks the terminase complex cytomegalovirus (CMV) needs to package its DNA into new virus particles. It is used to prevent CMV infection and disease after stem cell and kidney transplants, as tablets or by drip. It is sold as Prevymis.
Letermovir is taken into the liver by the transporters SLCO1B1 and SLCO1B3 and cleared mainly by UGT1A1 and UGT1A3 into bile. Studies have looked at SLCO1B1, UGT1A1 and ABCG2 variants for its blood levels. The findings come from a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Letermovir. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
SLCO1B1 rs4149032: Level 3. Metabolism/PK. 1.
SLCO1B1 rs4149056: Level 3. Metabolism/PK. 1.
UGT1A1 rs4148323: Level 3. Metabolism/PK. 1.
Studies of how quickly the body processes this medication.
ABCG2 rs2231142: Allele T is not associated with exposure to letermovir as compared to allele G.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Agenerase (Protease Inhibitors)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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