Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Ustekinumab is a biologic medicine, a monoclonal antibody that blocks the shared p40 part of two immune signals, interleukin-12 and interleukin-23, which drive several inflammatory diseases. Injected every few months after a starting phase, it is used for plaque psoriasis, psoriatic arthritis, Crohn's disease and ulcerative colitis. It is sold as Stelara and as biosimilars.
As an antibody, ustekinumab is not broken down by drug-processing enzymes. The most discussed finding is HLA-C*06:02: people with psoriasis who carry it responded better in several studies. Others looked at immune genes such as IL12B, IL1B, TNFAIP3 and toll-like receptor genes. The findings come from a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Ustekinumab. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
TIRAP rs8177374: Level 3. Efficacy: Psoriasis. 1.
TLR5 rs5744174: Level 3. Efficacy: Psoriasis. 1.
IL1B rs1143627: Level 3. Efficacy: Psoriasis. 1.
IL1B rs1143623: Level 3. Efficacy: Psoriasis. 1.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Aldara (Immune Response Modifiers)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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