Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Trifluoperazine is an older, high-potency phenothiazine antipsychotic that blocks dopamine D2 receptors. It is used for schizophrenia and other psychoses, and in some countries at low doses for severe anxiety. Movement side effects such as stiffness and restlessness are common. It is sold as Stelazine, among other names.
Trifluoperazine is broken down mainly by CYP1A2. The single gene study listed, from a study of several antipsychotics in schizophrenia, looked at EPM2A for response. The evidence is weak, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Trifluoperazine. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
EPM2A rs1415744: Level 3. Efficacy: Schizophrenia. 1.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Antipsychotics (class) (Antipsychotics)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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