Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Tafenoquine is an antimalarial of the 8-aminoquinoline family, a long-acting relative of primaquine. A single dose clears the dormant liver stage of vivax malaria, so the infection does not come back, and a weekly form is used to prevent malaria in travellers. It is sold as Krintafel and Arakoda.
G6PD protects red blood cells from chemical stress. In people with G6PD deficiency, tafenoquine can cause haemolysis, the breakdown of red blood cells, and because it stays in the body for weeks the effect cannot be stopped quickly; the US label therefore requires G6PD testing before it is given. CPIC has published a guideline on G6PD that covers tafenoquine. A study has also looked at CYP2D6 and whether vivax malaria comes back.
Clinical guidelines that name a gene for Tafenoquine. They sort people into groups by the gene copies they carry.
US FDA: G6PD. Variable · Deficient with CNSHA · Deficient.
Every published finding on gene variants and Tafenoquine. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
rs62103056: Level 3. Efficacy: Malaria. 1.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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