Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Chloroquine is one of the oldest antimalarials: it builds up inside the parasite's digestive vacuole and stops it from safely disposing of haem from the blood it feeds on. It is used to treat and prevent malaria where the parasites are still sensitive to it, and for amoebic liver abscess; resistance is now widespread. It is sold as Aralen, among other names.
The US FDA lists G6PD for chloroquine, because in people with G6PD deficiency antimalarials of this family can cause haemolysis, the breakdown of red blood cells. Chloroquine is broken down by CYP2C8, CYP3A4 and CYP2D6. There is no CPIC or DPWG guideline, and few studies have looked at genes for this medicine.
Clinical guidelines that name a gene for Chloroquine. They sort people into groups by the gene copies they carry.
US FDA: G6PD. Deficient · Variable · Deficient with CNSHA.
Every published finding on gene variants and Chloroquine. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
G6PD G6PD A- 202A_376G, G6PD B (reference), G6PD Mediterranean Haplotype, G6PD Mediterranean, Dallas, Panama, Sassari, Cagliari, Birmingham: Level 4. Toxicity: Hemolytic Anemia. 6.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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