Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Sulindac is a non-steroidal anti-inflammatory drug (NSAID) given as an inactive prodrug that the body turns into its active sulfide form. It is used for osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, gout attacks and shoulder pain, and has been studied for shrinking bowel polyps in familial adenomatous polyposis. It is sold as Clinoril, among other names.
Sulindac is reduced to its active sulfide form and inactivated to its sulfone form by the enzyme FMO3. The gene studies on it looked at FMO3 variants, which were linked to the balance between these forms and, in polyposis, to how well it worked. The findings come from a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Sulindac. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
FMO3 rs2266782: Level 3. Metabolism/PK. 1.
FMO3 rs2266780: Level 3. Metabolism/PK. 1.
Studies of how quickly the body processes this medication.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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