Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Piroxicam is a non-steroidal anti-inflammatory drug (NSAID): it blocks the COX enzymes that make prostaglandins, the signals behind pain and inflammation. It lasts a long time in the body, so it is taken once a day. It is used for osteoarthritis and rheumatoid arthritis. It is sold as Feldene, among other names.
Piroxicam is broken down mainly by the liver enzyme CYP2C9, and because it already stays in the body for days, slower clearance has a large effect. People with reduced-function versions such as *2 and *3 have higher, longer-lasting levels. CPIC has published a guideline on CYP2C9 and the NSAIDs, including piroxicam, and the US FDA lists the pair. A few studies have also looked at CYP2C8.
Clinical guidelines that name a gene for Piroxicam. They sort people into groups by the gene copies they carry.
CPIC guideline: CYP2C9. CYP2C9 activity score 0 to 2. Strong. 2020.
US FDA: CYP2C9. CYP2C9 activity score 0 to 0.5.
Every published finding on gene variants and Piroxicam. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
CYP2C9 CYP2C9*1, CYP2C9*2, CYP2C9*3: Level 1A · replicated. Metabolism/PK. 2.
Studies of how quickly the body processes this medication.
Studies of how well it worked in people carrying a variant.
CYP2C8 rs10509681: Allele T is not associated with response to piroxicam as compared to allele C.
CYP2C8 rs11572080: Allele T is not associated with response to piroxicam as compared to allele C.
CYP2C9 rs1057910: Allele C is not associated with response to piroxicam as compared to allele A.
CYP2C9 rs1799853: Allele T is not associated with response to piroxicam as compared to allele C.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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