Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Sulfadoxine is a long-acting sulfonamide that blocks folate production in malaria parasites. It is used combined with pyrimethamine (SP, Fansidar) for intermittent preventive treatment of malaria in pregnancy and, with amodiaquine, for seasonal malaria prevention in children in parts of Africa.
In people with G6PD deficiency, sulfonamides such as sulfadoxine can cause haemolysis, the breakdown of red blood cells. The gene studies listed looked at G6PD in people receiving sulfadoxine-pyrimethamine, often combined with other antimalarials. The findings come from a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Sulfadoxine. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
G6PD rs1050828: Level 3. Toxicity: Malaria, Malaria, Falciparum. 1.
G6PD;IKBKG rs1050828: Level 3. Toxicity. 1.
G6PD G6PD B (reference), G6PD Mediterranean, Dallas, Panama, Sassari, Cagliari, Birmingham: Level 3. Toxicity: Hemolysis. 1.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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