Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Sertraline is one of the most widely prescribed antidepressants, of the SSRI group: it keeps more of the messenger serotonin available between nerve cells. It is used for depression, panic disorder, social anxiety, obsessive-compulsive disorder, post-traumatic stress disorder and severe premenstrual symptoms. It is sold as Zoloft and Lustral, among other names.
Sertraline is broken down by several liver enzymes, mainly CYP2C19 and CYP2B6. People with two low-function CYP2C19 copies (poor metabolizers) have clearly higher blood levels, and slower CYP2B6 versions raise them too. CPIC has published a guideline on CYP2C19 and CYP2B6 for sertraline, and DPWG on CYP2C19. Many studies have looked at serotonin genes such as HTR2A and SLC6A4 and at the transporter ABCB1 for how well it works, with weaker evidence.
Clinical guidelines that name a gene for Sertraline. They sort people into groups by the gene copies they carry.
Every published finding on gene variants and Sertraline. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
CYP2C19 CYP2C19*1, CYP2C19*2, CYP2C19*3, CYP2C19*17: Level 1A · replicated. Metabolism/PK: Mental Disorders. 6.
CYP2B6 CYP2B6*1, CYP2B6*4, CYP2B6*6, CYP2B6*9: Level 1A · replicated. Metabolism/PK. 4.
HTR1A rs6295: Level 3. Efficacy: Depressive Disorder, Major Depressive Disorder. 7.
ABCB1 rs2032583: Level 3. Efficacy: Depression, Depressive Disorder, Major Depressive Disorder. 3.
Studies of how quickly the body processes this medication.
Studies of how well it worked in people carrying a variant.
Studies of how much of the drug people needed or tolerated.
Studies of side effects in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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