Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Fluvoxamine is an antidepressant of the SSRI group: it keeps more of the messenger serotonin available between nerve cells. It is used mainly for obsessive-compulsive disorder, and in some countries for depression and social anxiety. It strongly blocks several liver enzymes, so it interacts with many other medicines. It is sold as Luvox, among other names.
Fluvoxamine is broken down partly by the liver enzyme CYP2D6, along with CYP1A2. People with no working CYP2D6 copies (poor metabolizers) have higher blood levels. CPIC has published a guideline on CYP2D6 and fluvoxamine, and the US FDA lists an effect on drug levels. Studies have also looked at serotonin genes such as SLC6A4, HTR2A and HTR1A for how well it works, with weaker evidence.
Clinical guidelines that name a gene for Fluvoxamine. They sort people into groups by the gene copies they carry.
CPIC guideline: CYP2D6. CYP2D6 activity score 0 to 6 or more. Strong. 2023.
US FDA: CYP2D6. CYP2D6 activity score 0 to 1.
Every published finding on gene variants and Fluvoxamine. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
CYP2D6 CYP2D6*1, CYP2D6*4, CYP2D6*5, CYP2D6*6, CYP2D6*10, CYP2D6*14: Level 1A · replicated. Metabolism/PK: Depressive Disorder. 10.
SLC6A4 SLC6A4 HTTLPR long form (L allele), SLC6A4 HTTLPR short form (S allele): Level 3. Efficacy: Major Depressive Disorder. 8.
HTR1A rs6295: Level 3. Efficacy: Depressive Disorder, Major Depressive Disorder. 7.
ABCB1 rs2032583: Level 3. Efficacy: Depression, Depressive Disorder, Major Depressive Disorder. 3.
Studies of how quickly the body processes this medication.
Studies of how well it worked in people carrying a variant.
Studies of how much of the drug people needed or tolerated.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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