Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Triptans are a class of migraine medicines that activate serotonin 5-HT1B and 5-HT1D receptors, narrowing swollen blood vessels around the brain and blocking the release of pain-signalling substances. The class includes sumatriptan, rizatriptan, zolmitriptan, eletriptan, naratriptan, almotriptan and frovatriptan, taken at the start of a migraine attack. This page collects studies on triptans as a group.
The gene studies listed for the class came from a genome-wide study of triptan response, which looked at migraine risk genes such as PRDM16, LRP1, PHACTR1 and ASTN2. Individual triptans are broken down by different routes: MAO-A for sumatriptan and rizatriptan, CYP3A4 for eletriptan and almotriptan, and CYP1A2 for zolmitriptan and frovatriptan. There is no CPIC or DPWG guideline.
Every published finding on gene variants and Triptans. Upload your DNA file to see which of these rows apply to you.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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