Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Rizatriptan is a triptan migraine medicine that activates serotonin 5-HT1B and 5-HT1D receptors, narrowing swollen blood vessels around the brain and blocking the release of pain-signalling substances. It is taken at the start of a migraine attack, as tablets or melt-in-the-mouth wafers, and acts fairly quickly. It is sold as Maxalt.
Rizatriptan is broken down mainly by monoamine oxidase A (MAO-A), not by CYP enzymes. Studies have looked at MAOA, its target gene HTR1B, the dopamine receptor gene DRD2, GRIA1 and inflammation genes for how well it relieved migraine. The findings come from a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Rizatriptan. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
DRD2 rs6275: Level 3. Efficacy: Migraine without Aura. 1.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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