Salmeterol (Serevent)

Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.

About Salmeterol

What it is

Salmeterol is a long-acting beta-2 agonist (LABA): it relaxes airway smooth muscle for about 12 hours. It is used twice daily, always together with an inhaled corticosteroid in asthma (as in Advair or Seretide), and for COPD. It is sold as Serevent.

How genes come into it

Salmeterol is broken down by CYP3A4. The gene studies on it looked at ADRB2, the beta-2 receptor it acts on: the Arg16Gly variant (rs1042713) was linked in some studies to fewer benefits or more flare-ups in children with asthma on regular LABA treatment, rated at PharmGKB level 2A, but prospective trials have not confirmed a clinically useful difference. There is no CPIC or DPWG guideline.

What research found

Every published finding on gene variants and Salmeterol. Upload your DNA file to see which of these rows apply to you.

Rated evidence (1 rated variant)

PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.

ADRB2 rs1042713: Level 2A · replicated. Efficacy: Asthma. 7.

Response (7 findings)

Studies of how well it worked in people carrying a variant.

ADRB2 rs1042713: Genotype AA is associated with decreased response to salmeterol in children with Asthma.

ADRB2 rs1042713: Allele G is associated with increased response to salmeterol in children Asthma as compared to allele A.

ADRB2 rs1042713: Genotype AA is associated with decreased response to salmeterol in people with Asthma as compared to genotype GG.

ADRB2 rs1042713: Allele A is not associated with response to fluticasone propionate and salmeterol in people with Asthma as compared to allele G.

Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.

Related Drugs

More drugs from the same category

Berotec (Beta-2 Agonists)

Beta-2 Agonists (class) (Beta-2 Agonists)

Brethine (Beta-2 Agonists)

Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.

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Content updated September 2026.

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