Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Salbutamol (albuterol) is a short-acting beta-2 agonist: it activates beta-2 receptors on the smooth muscle of the airways, relaxing them within minutes. Inhaled, it is the standard reliever for asthma attacks and COPD symptoms and is used before exercise to prevent wheezing. It is sold as Ventolin and ProAir, among other names.
Salbutamol is cleared mainly by sulphate conjugation (SULT1A3) and the kidneys. The most studied gene is ADRB2, the beta-2 receptor it acts on: its Arg16Gly variant was linked in some studies to a different response with regular use, but later trials did not confirm a clinically useful effect. Genome-wide studies flagged CRHR2, SPATS2L and others for bronchodilator response, more often in children of African and Latino ancestry. There is no CPIC or DPWG guideline.
Every published finding on gene variants and Ventolin. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
ADRB2 rs1042713: Level 3. Efficacy: Asthma. 5.
CRHR2 rs2267715: Level 3. Efficacy: Asthma. 1.
rs9552679: Level 3. Efficacy: Asthma. 1.
rs1423515: Level 3. Efficacy: Asthma. 1.
Studies of how well it worked in people carrying a variant.
Studies that do not fall into the groups above.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Beta-2 Agonists (class) (Beta-2 Agonists)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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