Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Rosiglitazone is a thiazolidinedione (glitazone): it activates PPAR-gamma, a switch in fat and muscle cells that makes the body more sensitive to insulin. It was used for type 2 diabetes; concerns about heart risks led to restrictions, and it was withdrawn in Europe in 2010, though it remains available in some countries. It is sold as Avandia.
Rosiglitazone is broken down mainly by CYP2C8, and the CYP2C8*3 version has been linked in studies to faster clearance and a weaker effect on blood sugar. Studies have also looked at its target PPARG, at SLCO1B1 and at PAX4 and LPIN1 for response. The findings come from single or a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Rosiglitazone. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
CYP2C8 CYP2C8*1, CYP2C8*3: Level 3. Metabolism/PK. 3.
CYP2C8 CYP2C8*1, CYP2C8*3: Level 3. Efficacy. 3.
CYP2C8 CYP2C8*1, CYP2C8*3: Level 3. Toxicity. 2.
LPIN1 rs10192566: Level 3. Efficacy: Diabetes Mellitus, Type 2. 1.
Studies of how quickly the body processes this medication.
Studies of how well it worked in people carrying a variant.
Studies of how much of the drug people needed or tolerated.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Chiglitazar (Thiazolidinediones)
Thiazolidinediones (class) (Thiazolidinediones)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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