Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Rocuronium is a non-depolarising muscle relaxant: it blocks acetylcholine receptors at the junction between nerve and muscle, relaxing skeletal muscles during anaesthesia so a breathing tube can be placed and surgery performed. Its effect can be reversed quickly with sugammadex. It is sold as Zemuron and Esmeron, among other names.
Rocuronium is taken up by the liver through the transporters SLCO1A2 and SLCO1B1 and excreted in bile. Studies, mostly from China, linked SLCO1A2 and SLCO1B1 variants to how long its effect lasted and to its levels. The findings come from a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Rocuronium. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
SLCO1A2 rs7967354: Level 3. Dosage. 1.
IAPP;SLCO1A2 rs11045995: Level 3. Dosage. 1.
ABCB1 rs1128503: Level 3. Efficacy. 1.
SLCO1B1 rs2306283: Level 3. Efficacy. 1.
Studies of how quickly the body processes this medication.
Studies of how well it worked in people carrying a variant.
Studies of how much of the drug people needed or tolerated.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Anectine (Neuromuscular Blockers)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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