Raw research findings for this medication. Mostly single studies, not curated or confirmed robust.
Rifampicin (rifampin) is an antibiotic that blocks bacterial RNA polymerase, the enzyme bacteria need to read their genes. It is a cornerstone of tuberculosis treatment, always with other antibiotics, and is also used for leprosy and some serious staphylococcal infections. It strongly speeds up many liver enzymes, so it interacts with many medicines, and it turns urine and tears orange. It is sold as Rifadin, among other names.
Rifampicin is taken into the liver by the transporter SLCO1B1 and cleared by the enzyme AADAC; studies have linked variants in both to its blood levels. Studies of tuberculosis treatment have also looked at NAT2 and other genes for liver injury, but that link mainly concerns isoniazid, given at the same time. The findings come from single or a few studies, and there is no CPIC or DPWG guideline.
Every published finding on gene variants and Rifampin. Upload your DNA file to see which of these rows apply to you.
PharmGKB weighs all studies of a variant and rates how strong the evidence is, from 1A (strongest) to 4.
GSTP1 rs1695: Level 3. Toxicity: Drug-induced liver injury, Tuberculosis. 3.
TNF rs1800629: Level 3. Toxicity: Toxic liver disease, Tuberculosis. 2.
RIPOR2 rs10946737: Level 3. Toxicity: Tuberculosis. 2.
NOS2 rs11080344: Level 3. Toxicity: Toxic liver disease, Tuberculosis. 2.
Studies of how quickly the body processes this medication.
Studies of how well it worked in people carrying a variant.
Study findings and evidence levels: PharmGKB (CC BY-SA 4.0). Guidelines: CPIC and DPWG, as bundled in PharmCAT. Most studies were done mainly in people of European ancestry.
More drugs from the same category
Isoniazid (Antimycobacterials)
Myambutol (Antimycobacterials)
Not a prescribing recommendation. This page is educational information about pharmacogenomic research and clinical guidelines - it is not medical or dosing advice, and not a prediction of how any medication will work for you. Never start, stop, or change a medication or dose based on it; talk to your doctor or pharmacist, who can order clinical-grade testing if appropriate.
Content updated September 2026.
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